Email: jwchen@ycit.edu.cn
Tel: 13815576691
陈景文，1967年8月生，1990年7月大学毕业，获化学专业理学学士学位；1998年4月获中南大学分析化学专业理学硕士学位；2005年5月获南京大学无机化学专业理学博士学位。1999年1月进盐城工学院化工系工作，2002年被聘为盐城工学院校内副教授，2006年被聘为中南大学、江苏大学、常州大学兼职硕士研究生导师，2008年入选“江苏省普通高等学校青蓝工程中青年学术带头人”培养人选，同年被聘为盐城工学院校内教授，2010年晋升为教授。2006—2017年任盐城工学院分析测试中心主任，2012年9月—2016年9月任盐城市机械学会理化分会副主任。一直从事应用化学专业的教学及科研工作，主要研究方向为功能化合物的设计、合成及其应用基础研究；光谱分析。曾完成江苏省自然科学基金项目两项；江苏省高校自然科学研究计划项目两项；第三十九批中国博士后科学基金资助项目一项；江苏省分析标准研究课题一项；江苏省新型环保重点实验室及滩涂生物资源与环境保护重点建设实验室开放基金项目各一项；完成校企合作项目六项，在研一项；作为主要成员参与教育部博士点基金新教师项目“金属配合物的抗肿瘤活性及其作用机理研究”（No.20070284065）和国家自然科学基金面上项目“新型低毒性铂类抗癌药物的理性设计和作用机制”（No.30870554）的研究工作。研究成果曾先后两次获盐城市科技进步二等奖，在中、外文学术期刊上发表论文39篇，其中SCI论文35篇，他引次数近千次。从本组实验室已毕业硕士研究生16名，博士研究生1名，已在多个行业发挥着中坚作用，目前在读研究生1名。
Research Interests：
1． Development of light-emitting and light-filtering materials and their optoelectronic applications in LEDs/OLEDs, photodetectors, optical thermometry, electrochromic devices;
2． Development of synthetic receptors for the selective detection of analytes in complex solutions, and colorimetric and fluorimetric chemosensors for sensing biologically- and environmentally-important species, fluorescent switches, and the study of the underlying photophysical and photochemical signaling as well as recognition processes;
3． Design and synthesis of new metal complexes as metalloenzyme models, enzyme inhibitors/activators, as well as their action mechanism and biotoxicology research.
Selected Journal Publications in Recent Years
1． Run Cheng, Qingyun Yuan, Song Zou, Yueyuan Yin, Cheng Ding, Chen Jingwen*, The role of the alkyl hydroxyl of thiosemicarbazones in activation of mushroom tyrosinase activity. Biorganic Chemistry 2023, Submitted.
2． Shuhong Cao, Run Cheng, Hongxia Liu, Wenyan Shi, Qingyun Yuan, Jingwen Chen*, Comparative studies of three isatin-thiosemicarbazones against corrosion of AA6060 aluminum alloy exposed to acidic NaCl medium. Journal of Molecular Structure, 2022, 1270, 133835. (https://doi.org/10.1016/j.molstruc.2022.133835)
3． Shuhong Cao, Dandan Wang, Run Cheng, Wenyan Shi, Qinfang Zhang, Huajin Zeng, Jingwen Chen*, Modulation of the lipophilicity and molecular size of thiosemicarbazone inhibitors to regulate tyrosinase activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 281, 121590. (https://doi.org/10.1016/j.saa.2022.121590)
4． Run Cheng, Wenyan Shi, Qingyun Yuan, Ruiren Tang, Jingwen Chen*, et al., 5-Substituted isatin thiosemicarbazones as inhibitors of tyrosinase: Insights of substituent effects. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 255, 119669. (https://doi.org/10.1016/j.saa.2021.119669)
5． Qingyun Yuan, Run Cheng, Cheng Ding, Chen Jingwen*, et al., Isatin thiosemicarbazone derivatives as inhibitors against corrosion of AA6060 aluminium alloy in acidic chloride medium: Substituent effects. Journal of Materials Research and Technology, 2020, 9 (5) 11935–11947. (https://doi.org/10.1016/j.jmrt.2020.08.012)
6． Shuhong Cao, Run Cheng, Ruiren Tang, Xiuli Yang, Chen Jingwen*, et al., Dinuclear copper(II) complexes of “end-off” bicompartmental ligands: Alteration of the chelating arms on ligands to regulate the reactivity of the complexes towards DNA. Journal of Inorganic Biochemistry, 2019, 192 (3) 126–139. (https://doi.org/10.1016/j.jinorgbio.2018.12.014)
7． Ying Wang, Jingwen Chen, Hongmei Zhang,Yanqing Wang, et al., Construction of doxorubicin-conjugated lentinan nanoparticles for enhancing the cytotoxocity effects against breast cancer cells. Colloids and Surfaces A, 2019, 579, 123657. (https://doi.org/10.1016/j.colsurfa.2019.123657)
8． Shuhong Cao, Chen Ligen, Chen Jingwen*, et al., α(N)-Heterocyclic thiosemicarbazones: iron chelators that are promising for revival of gallium in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16 (8) 973-991. (https://doi.org/10.2174/1871520616666160310142012)
9． Shuhong Cao, Xinyu Jiang, Jingwen Chen*, Effect of Zinc(II) on the interactions of bovine serum albumin with flavonols bearing different number of hydroxyl substituent on B-ring. Journal of Inorganic Biochemistry, 2010, 104 (2) 146–152. (https://doi.org/10.1016/j.jinorgbio.2009.10.014)
10． Yingyu Chen, Jingwen Chen*, Xiaoqing Chen, et al., Synchronous fluorescence analysis of phytate in food. Microchimica Acta, 2009, 164 (1–2) 35–40. (https://doi.org/10.1007/s00604-008-0026-1)
11． Yingyu Chen, Jingwen Chen*, Xiaoqing Chen*, et al., Fluorimetric determination of phytic acid in urine based on replacement reaction. Analytica Chimica Acta, 2007, 605 (2) 185–191. (https://doi.org/10.1016/j.aca.2007.10.041)
12． Jingwen Chen, Xiaoyong Wang, et al., A trinuclear copper(II) complex of 2,4,6-tris(di-2-pyridylamine)-1,3,5-triazine shows prominent DNA cleavage activity. Inorganic Chemistry, 2007, 46 (8) 3306–3312. (https://doi.org/10.1021/ic0614162)
13． Jingwen Chen, Xiaoyong Wang, et al., An asymmetric dizinc phosphodiesterase model with phenolate and carboxylate bridges. Inorganic Chemistry, 2005, 44 (10) 3422–3430. (https://doi.org/10.1021/ic048654m)
Books and Book Chapters
1． 陈景文，唐亚文，《化学与社会》，南京大学出版社，2015.
2． 张劲松，《现代化工企业管理》，陈景文：《生产过程管理—质量管理》，化学工业出版社，2015.
Filed Patents
1． 陈景文，曹淑红，王丹丹，“一种微反应装置及其在连续制备磺酰氯化合物中的应用” （202310234522.7）
2． 陈景文，曹淑红，王丹丹，“一种采用气溶胶进料的微通道光引发反应装置及其应用” （202310218390.9）
3． 苏凡，陈景文，曹淑红，梁通艺，袁杰逸，张勤芳，“一种Mn(IV)掺杂的氟硅酸钾红色荧光粉的改性方法”（202211583284.2）
4． 陈景文，曹淑红，王玉琴，陈浩，邹松，殷月媛，“一种萃取精馏分离纯化氟苯的方法” （CN 110937979 A）
5． 陈景文，王玉琴，曹淑红，杨迪，王玉洁，“一种自加热驱灭蚊片” （202010083159.X）
6． 陈景文，曹淑红，全梅花，杨迪，陶汇荣，肖新，许欣怡，“一种利用锌-空气微电池自发热的驱灭蚊片” （202010085508.1）
7． 陈景文，丁成，曹淑红，崔恩田，马成建，闵敏，“一种利用铁-空气微电池自发热的驱灭蚊片” （202010083167.4）
